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Vaccine Progress, Approval, and Deployment

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brad465

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Perhaps we should wait to see what effect the vaccines do have, and then consider how the risks look, rather than impose arbitrary timelines on what we do or do not consider acceptable. That's not about what you or I want (I have my own list of events and encounters in mind), but about raw, hard, numbers. And, unlike some, I don't assume that those implementing measures I personally dislike are doing so in bad faith, or with some kind of desire to control us - but in a serious attempt to manage the risks and consequences of a pandemic.
If the vaccine doesn't turn out to be very effective for now the apparent seasonality will help us get through the summer with little concern, then we should just do what we do with flu: tweak the vaccine for whatever strain(s) causes concern at the time and roll it out to the same people who get a flu jab, and maybe like just recently, roll the vaccine out to over 50s as well.
 
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Carlisle

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If the vaccine doesn't turn out to be very effective for now the apparent seasonality will help us get through the summer with little concern, then we should just do what we do with flu: tweak the vaccine for whatever strain(s) causes concern at the time and roll it out to the same people who get a flu jab, and maybe like just recently, roll the vaccine out to over 50s as well.
Is it thought likely a months lockdown would be proposed around November to issue boosters to everybody,? I hope not but have a gut ffeeling something like that well may happen
 
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Tezza1978

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Is it thought likely a months lockdown would be proposed around November to issue boosters to everybody,? I hope not but have a gut ffeeling something like that well may happen
Unlikely. The Times was reporting it would be probably supplied to independent pharmacists/Boots etc to give at the same time as the flu jab.
 

Bantamzen

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Is it thought likely a months lockdown would be proposed around November to issue boosters to everybody,? I hope not but have a gut ffeeling something like that well may happen
Why would you need a lockdown? Just offer it out along with flu jabs and job done.
 

Class 33

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A months lockdown in November??!! Absolutely no way! And thousands of businesses and millions of people messed about again??!! Once this ridiculous third lockdown is finally over, this has to be the very last lockdown now. High time for life to get back to normal.
 
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A months lockdown in November??!! Absolutely no way! And thousands of businesses and millions of people messed about again??!! Once this ridiculous third lockdown is finally over, this has to be the very last lockdown now. High time for life to get back to normal.
Indeed, I have been very supportive of this lockdown as let's face it. we opened up too much in the run-up to Christmas and are paying for it. However we cannot keep locking down, it's such a blunt tool, as you state it destroys livelihoods, education etc and not to mention the WHO advises against using it unless absolutely necessary
 

swr444

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From what i've heard, they'll be starting with the over 65's vaccination from tomorrow possibly. Not sure if this has already been mentioned
 

Dent

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From what i've heard, they'll be starting with the over 65's vaccination from tomorrow possibly. Not sure if this has already been mentioned

Haven't they already started on that group in areas where all the over 70s have been done?
 

yorkie

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Is it thought likely a months lockdown would be proposed around November to issue boosters to everybody,? I hope not but have a gut ffeeling something like that well may happen
This is crazy. I refuse to normalise harmful lockdowns. There is no need for it and there can be no justification for this.

The idea that we need to cause hyperinflation, debt, mental & physical health issues etc in the never ending pursuit of quantity of life over quality has to stop.

Once the Over 70s have had sufficient time to gain reasonable immunity and the Over 65s have been vaccinated, that's got to be it as far as lockdowns are concerned.

Any proposals for longer/harsher/additional lockdowns don't belong in this thread though.
 

Carlisle

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Unlikely. The Times was reporting it would be probably supplied to independent pharmacists/Boots etc to give at the same time as the flu jab.
i really hope your right, I’ve just currently got zero confidence in this government not being panicked into another lockdown should infection rates rise again, as is likely to some degree next winter
 

swr444

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Haven't they already started on that group in areas where all the over 70s have been done?
They're not allowed, im volunteering at the York site and they're waiting for the governments approval to go ahead with it
 

philosopher

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If the vaccine doesn't turn out to be very effective for now the apparent seasonality will help us get through the summer with little concern, then we should just do what we do with flu: tweak the vaccine for whatever strain(s) causes concern at the time and roll it out to the same people who get a flu jab, and maybe like just recently, roll the vaccine out to over 50s as well.
I have come across this article from Unherd about the AztraZeneca vaccine and the South Africa variant
https://unherd.com/2021/02/how-worrying-is-the-south-africa-variant/
First: this is an extremely uncertain finding. As the virologist Müge Çevik points out, the study was small: it had 1,700 participants, which sounds reasonable enough, but your study’s statistical power comes from the number of cases, not the number of people in the study. And there were only 42 cases of coronavirus in the control and the treatment arm put together.

Of those 42, 19 had been given the real vaccine, and 23 had the placebo. The study itself isn’t available, but screenshots taken from an online briefing say that it is believed to be 22% effective. But because of the small numbers, the uncertainty around them is huge: the 95% uncertainty interval stretches from 58% to -49% efficacy.
Three things I have noticed:

First the efficacy is 22%, not the 10% widely reported. OK, this is still not great, but it is better than 10%.
Second the sample size is very small, with only 1700 participants.
Third there is a massive confidence interval of between -49% and 58%

It would not surprise me if the low reported efficacy is due to bad luck. Other vaccine trials report a lot higher efficacy against the South Africa variant.
 

Spamcan81

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They're not allowed, im volunteering at the York site and they're waiting for the governments approval to go ahead with it

Some areas have started on the over 65 - 69 cohort. A 68 year old mate of mine near Blackpool had his jab today.
 

Yew

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From what i've heard, they'll be starting with the over 65's vaccination from tomorrow possibly. Not sure if this has already been mentioned
That makes sense
I have come across this article from Unherd about the AztraZeneca vaccine and the South Africa variant

Three things I have noticed:

First the efficacy is 22%, not the 10% widely reported. OK, this is still not great, but it is better than 10%.
Second the sample size is very small, with only 1700 participants.
Third there is a massive confidence interval of between -49% and 58%

It would not surprise me if the low reported efficacy is due to bad luck. Other vaccine trials report a lot higher efficacy against the South Africa variant.
With confidence intervals as massive as that, there's almost no point in even reading the study
 

Mag_seven

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Some areas have started on the over 65 - 69 cohort. A 68 year old mate of mine near Blackpool had his jab today.

Even though different areas operate at different vaccination speeds, they need to keep going and not wait for other areas to catch up.
 

Bantamzen

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I think that the vaccinations won't stop the pandemic. Hope I am wrong.
Vaccinations will massively reduce the number of people becoming seriously ill, which in turn will reduce the time & exposure the virus will have to transmit, which will reduce its spread & remove the impact it has on global health services. That will end the pandemic, it won't remove the virus, but that was never a feasible option away from lazy media hacks & politicians looking to score points.
 

hwl

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indeed the question for those 'in the know' has never been whether they reduce transmission, but how much they do.
Agreed, "how much" has big impacts in 6-8 weeks time onwards
Probably through inflation at some point, though that's arguably a topic for a whole new thread.
The BoE is expecting a consumer spending surge as there is about £130bn in extra accumulated savings through not going on holiday/pub etc.
 

Bantamzen

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Agreed, "how much" has big impacts in 6-8 weeks time onwards

The BoE is expecting a consumer spending surge as there is about £130bn in extra accumulated savings through not going on holiday/pub etc.
Accumulated savings? You mean for people who have had a 20% pay reduction for much of a year, or those who have lost their jobs altogether. Even those that might have saved money earlier in the year will be picking up additional housing costs from working & schooling from home. Plus there are those who have accumulated additional personal debt through a combination of the above. Some people might have some spare cash, many will not. And I suspect a fair amount of that "saved" money is already spoken for.
 

brad465

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Agreed, "how much" has big impacts in 6-8 weeks time onwards

The BoE is expecting a consumer spending surge as there is about £130bn in extra accumulated savings through not going on holiday/pub etc.
I don't know who the BoE have been talking to but it won't be people on the breadline, recently unemployed or anyone who realises just how close we are to a "rainy day" as a result of the last year so therefore won't spend galore. Even if all restrictions and/or the vaccine programme were lifted/completed tomorrow I doubt a spending spree will ever happen after.
 

hwl

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If the vaccine doesn't turn out to be very effective for now the apparent seasonality will help us get through the summer with little concern, then we should just do what we do with flu: tweak the vaccine for whatever strain(s) causes concern at the time and roll it out to the same people who get a flu jab, and maybe like just recently, roll the vaccine out to over 50s as well.
Vaccinations will massively reduce the number of people becoming seriously ill, which in turn will reduce the time & exposure the virus will have to transmit, which will reduce its spread & remove the impact it has on global health services. That will end the pandemic, it won't remove the virus, but that was never a feasible option away from lazy media hacks & politicians looking to score points.

The less reported bit of the South African trial was that 87% of those vaccinated with the Oxford/AZ vaccine had a good T-cell response when they caught the 501+484 mutation (good news as this helps prevents serious cases), it is just the antibody response is poor hence lots of mild cases who are good at spreading, the same thing is in seen in SA with second infections (at quite high rates) in those who had an old strain last year and have then caught the new 501+484 mutation in the last 2 months.

On a positive note: This is not a flu family virus there are far far fewer mutations possible in the spike, many offering no advantage and about 5% of potential mutations would stop it entering cells to replicate.
 

Spamcan81

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Must be restrictions on the vaccination hubs compared to GP surgeries / hospitals

I'm sure there will be local variations. I'm 68 and a couple of weeks ago I was told that at the then current rate of progress, I could expect my invite in three weeks. Fingers crossed for next week then.
 

hwl

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Accumulated savings? You mean for people who have had a 20% pay reduction for much of a year, or those who have lost their jobs altogether. Even those that might have saved money earlier in the year will be picking up additional housing costs from working & schooling from home. Plus there are those who have accumulated additional personal debt through a combination of the above. Some people might have some spare cash, many will not. And I suspect a fair amount of that "saved" money is already spoken for.
I don't know who the BoE have been talking to but it won't be people on the breadline, recently unemployed or anyone who realises just how close we are to a "rainy day" as a result of the last year so therefore won't spend galore. Even if all restrictions and/or the vaccine programme were lifted/completed tomorrow I doubt a spending spree will ever happen after.
Heading slightly off topic....

Their data not mine but they do have a good long term track record in understanding this.
The financial impacts have been very asymmetric within society with most of the negative financial impacts in 30% of the working population.
 

Bantamzen

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Heading slightly off topic....

Their data not mine but they do have a good long term track record in understanding this.
The financial impacts have been very asymmetric within society with most of the negative financial impacts in 30% of the working population.
Maybe they do have a better view of it, I just wonder if they are being a bit optimistic. A lot of winter bills, credit cards etc won't yet have been paid. But as you say, that's probably for another thread.
 

Darandio

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Their data not mine but they do have a good long term track record in understanding this.

Well along with @Bantamzen i'm still not that convinced. They may well have a great track record in the past but we've never been in quite this situation before, this is learn as you go along stuff.
 

Nicholas Lewis

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This is crazy. I refuse to normalise harmful lockdowns. There is no need for it and there can be no justification for this.

The idea that we need to cause hyperinflation, debt, mental & physical health issues etc in the never ending pursuit of quantity of life over quality has to stop.

Once the Over 70s have had sufficient time to gain reasonable immunity and the Over 65s have been vaccinated, that's got to be it as far as lockdowns are concerned.

Any proposals for longer/harsher/additional lockdowns don't belong in this thread though.
They've already moved the goalpost out to everyone over 50 despite cohorts 1-4 being the group that needed doing to make a difference and CRG have defacto signed off on that now so if there not going to pushback we are stuck with May at the earliest. Now the reality is we have seasonal suppression overlaid on vaccines so there is no reason that restrictions can be wound right back from May to Sept. My view is we will extensive oversight going into Autumn to detect the virus growing again as it won't be till then we will know how effective vaccines are. So there needs to be a contingency plan for NHS to be resourced up to manage a higher caseload than a normal flu season plus shielding is going to be a necessity so lets find a way it can be done thats more supportive for those involved. My hope is this won't be required but we are in lockdown 3 because of inaction by govt last to manage the situation. Yes the Kent variant may have caught them off guard but from my chair the warning signs were there in lockdown 2 that something wasn't right in Kent and had they been more cautious than worrying about Xmas we could have contained it.
 
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