Indirectly, but it doesn’t really. The culverted Fleet river goes round the front of the hotel, well clear of its basement, then heads north under the road before veering towards St Pancras. So effectively the river culvert defined the hotel position. The curve of the new concourse was then designed to integrate with the back of the hotel.
As I understood it, the Fleet, in its culvert, was diverted to make way for the Metropolitan Railway, and in particular the curve connecting it to the GN main line. This is the curve known as the "Hotel Curve" because the GN Hotel was built following the same curve. So the hotel, the culvert and the railway were designed at the same time.
One which hasn't been mentioned yet is Lincoln. The station was built astride the artificial channel known as the Sincil Dyke, which diverts excess water from the River Witham to pass to the south and east of the City Centre. Here is a view looking north. The tower on tghe left is part of the station buildings (the others are the cathedral, on the hill overlooking the station!) and a train (in blue and red Stagecoach livery) can be glimpsed along with some of the station signs directly above the dyke.
As a right of way existed along Sincil Bank, a footbridge was provided spanning the station, but with no direct access to the station. This was quite separate fropm the station's own footbridge, from which the next picture was taken, and which can be seen in the one below it.

Also in Lincoln, the old St Marks station (closed in 1985) was squeezed between the High Street and the River Witham (the girders of the bridge over the river can be seen in the foreground here)

The platforms themselves could only take four or five vehicles (this view shows two Class 120s and two Class 31s), and all trains had to stop clear of the barrow crossing at the east end (far end in this view) which was the only access to platform 2 (the one on the right in this view). The station had to handle 2+8 HSTs (and class 47- hauled 8 car trains before that) so the London end of any such train when standing in the station was in fact well beyond the bridge.