Millions of people in London, Essex, York and other areas face tougher Tier 2 Covid measures from Saturday, Health Secretary Matt Hancock has said.
Under this "high" alert level, there is a ban on households mixing indoors, including in pubs and restaurants.
Greater Manchester mayor Andy Burnham is resisting the region moving to Tier 3, ahead of a final decision on this.
More than half of England's population will now be living under high or very high-alert restrictions.
The areas to go into high alert restrictions this weekend are: London, Essex (apart from Southend and Thurrock), York, North East Derbyshire, Chesterfield, Erewash in Derbyshire, Elmbridge in Surrey, and Barrow in Furness, Cumbria.