If you were going to do a wholesale rebuild south of Hanslope Junction, then DF-DS-US-UF would be preferable as it then enables a single island platform for the minor stations and turnback sidings are trivial. Complications would come from the link to the Bletchley flyover (though there would be plenty of room to bring the lines down between the slow lines, the curvature would be interesting to say the least), the junctions around Willesden, but ironically, I think the tunnels around Euston are probably sufficient for getting the fast services to where they need to be - ironic as these will then all be rebuilt for the Euston rebuild!

Given most stations on the southern WCML have an island flanked by two side platforms you could then just close the side platforms off for the minor stations and vastly improve the safety situation of having fast trains passing though as well.