DDA in simple terms means disabled areas toilets etc.
And one design I'm thinking of at the moment, if it is only going to be Reading - Shenfeild / Abbey Wood etc. would be to have 1/3 and 2/3 doors, the ends of each of the carriage between the doors and ends being 2+2 (I'm assuming siemens seating) you can fit 16 2+2 seats between the doors and ends, thats 32, knock off 4 for a standard toilet and you have 28 comfy seats (assuming one toilet per carriage).
Between the doors have LU style seating, at a rough guess that's another 20 seats, but massess of standing space. Now we need to consider luggage space, easy, loose another four seats next to a door (on the outside bits) so now we have 24 comfy, 20 sideways seats, a big luggage rack, double width, and a toilet, per unit.
For the DDA/Cycle carriges, all the modifications would be in the 'end areas' I'd be looking at modifying it so that the 'toilet end' has space for two wheelchairs, working off the space useage in a 185, that would mean a whole end bit for the disabled toilet, for the wheelchair placement, place tip up seating in the centre part of the unit with an open partition to park them against, et voalla, space for four wheelchair users. The other half of the centre segment retains standard layout with seats and sideways seats.
The bike carriage is a similar deal, but the modification would be to remove the seats from half of one of the outer ends (possibly in the same carriage as the disabled area) and replace the nice seats with a bike and enhanced luggage area (like we see on Northern 150 units with the shelf that bikes go under) the seats on the oppo side would need to be replaced with the usual arrangement.
Next up, 1st class, we don't need much initally so lets have a small area of it at either far end, I get about 15 1st seats in 1/2 of a carriage, partitioned in the middle with a standard layout on the other side.
So, we now have 3 carriage layout designs
F = First Seat, S = Standard Seat (2+2), M = Metro Seat (Sideways), D = Disabled Area, B = Bike Space (Standing Space, approx)
Standard: 24S 20M (50)
Combined: 15F 10S 10M (25)
DDA/Bike: 18M 4D 4B (30)
So, 10 car formation if you please....
Driving Combined - 3 * Standard - 2* DDA/Bike - 3* Standard - Driving Combined
Gives us....
30 First Class Seats
164 Standard Class 2+2 Seats (Maybe some tables)
176 Sideways Seats concentrated either side of the middle
8 Wheelchair parking spots (also available for buggies?)
8 Full size bike spaces, may need rules about alighting in C London...?
~410 Standees
So a standard class capacity of....
750, with 30 First Class...
Now you can add more first for the cost of some standard, but I think the gist is available here as to what I'd have as the layout.
If the services are only say, 30 - 40% loaded outside of the core 1hr journey time, then most of them people get a nice seat.