Changing at Salford Crescent is certainly a better option than changing at Oxford Road, if ease of doing so is crucial. Otherwise, as you say, the vast majority of connections can easily be made on p4 at Oxford Road. Oxford Road is also ideal for those wanting the city, it's not that far a walk to St Peters Square for example.
I thoroughly dislike how long it takes to do Piccadilly to Oxford Road, and indeed onwards past Deansgate, when I'm in the area. So anything that helps improve that experience gets the thumbs-up from me!