As the line is a disused rail line, that formerly led in to Liverpool St station (now the Museum of Science and Industry) it doesn't have overhead wires.
The city centre section of the Metrolink (Deansgate-Castlefield to Victoria) is controlled by signals that show vertical, horizontal and slanted white lines, in some places these are attached to standard traffic lights. At Deansgate-Castlefield and Victoria stations there are signs informing drivers to switch to street running mode, which changes the horn to a quieter different pitched one that automatically sounds on moving off and presumably limits the speed significantly.