Interesting thread.
Like one of the early posters, I'm originally from Manchester, but after National Service and graduating in physics/engineering I found that professional jobs were very scarce in the Manchester area, but plentiful around London. That was in the 1960s. So working at Borehamwood, I bought my first home in Harpenden, and ended up in Milton Keynes in the 1980s as a result of my employer expanding and needing to relocate. Like others above, I echo the "which region are we in?" problem.
To throw another aspect in to the mix - I found it pleasant to leave Manchester and north Cheshire in the 1960s, where having a (good) degree wasn't appreciated by my workmates. I never found any such problem once I'd moved to the London area, except from one boss who fortunately for my sanity, got fired. In the 1960s at least, London was a much more cosmopolitan place than where I'd grown up. However, it's been good to see Manchester getting cleaned up over the last few decades, and it's certainly nearer to "wild" country.