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I do this quite regularly
Depending on times, I travel :
Glasgow Central - (via Motherwell) Carlisle - Newcastle
Glasgow QS - (via Falkirk High) Edinburgh - Newcastle
I did this trip a while ago and went Newcastle- Edinburgh (had a break) - Glasgow QS - Walk to Central - then back to Newcastle on the direct Scotrail service via Kilmarnock, Dumfries and Carlisle. Cracking day out.