Assuming the standard method of transition between series and parallel, one of the significant failure modes is the failure of contactors. I've not seen anything about loco S/P designs, but the 1500V EMUs had motors, wired in series with resistors across the 1500V supply up to about 20mph, at which speed the resistances would all be switched out. Then, to avoid having to break a nearly purely inductive circuit with a high running current, the centre point was switched to ground momentarily to allow the lower motor to be changed over to its own 1500V feed, with the resistor chain back in circuit. This meant that there was no arcing across the contactors by trying to open a circuit. The problem was that the sequencing of contactors was failrly critical as the short to ground produced a current surge before the reasitors on the upper motor could be switched back in. Sometimes there would be a repeated tripping of contactors more than 5 times before the drive settled down again.