I was brought up on BR(S) regular interval timetables (offpeak anyway) were taken for granted and I have been hooked on the Taktfahrplan concept since details were first reported in Modern Railways nearly 50 years ago. However:
Standardised departures are especially helpful at lower frequencies
Once you get down to 2-hourly, though, I am less certain that it matters. I don't mean we should put up with odd 5-minute variations, but where traffic is relatively light it is more important to run trains to fit the actual flows as best you can.
I also suspect that people are less likely to rely on memory for "23 past the odd hour" thoug I can't prove it.
An extreme example is Whitby, where a 3-hourly interval service beyond Nunthorpe fits the infrastructure neatly (NYMR and all) but doesn't fit with the school traffic.
Or the Settle and Carlisle, where the 90-minute intervals in the northbound morning "peak" meet the demand much better than the standard 2-hourly would.
(Yes, you can argue that the service on each should be more frequent, but leave that aside for this thread, please).
The problem arises where there is both a significant local flow and a significant connecting flow to cater for - fortunately this doesn't apply to either example.