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For the most interesting traction you need to be there on a weekday.
Here are my pictures from weekday rush hours in 2009, although that was a 'farewell' trip because since then lots more of the loco hauled stuff has gone.
http://frenchrailways.fotopic.net/c1775880.html
Possibly the simplest out and back trip from Lille is to Comines (a town with Belgian and French halves straddling the border). A few trains on this line are still 67400 diesel hauled, a contact recently reported a trip on this line
Join Europeanrail Yahoo group for loco diagrams and local gen from a UK Lille-resident expert
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Sorry, forgot to add the cutural tips!
ON the aforementioned 2009 trip with my wife, we did the following clockwise walking tour which took in most of the major sights (not all in the very centre of the city so you gate a chance to walk along some less crowded streets.
We were staying at the Novotel Centre Gares, but went by metro to
Lille Grand Palais then
Boulevard marechal Vaillant to
Noble Tour - a 15th century mediaeval tower the oldest fortification in Lille
Rue de déportés
Hotel de Ville
Porte de Paris (one of the three city gates)
Musee des Beaux Arts
Prefecture
Place Rihour
Grand Place
Ancien Bourse
Theatre
There's a good map here which highlights all the places in bright red:
http://www.planetware.com/map/lille-map-f-lill.htm
don't miss the incredible 17th century relief maps of fortified towns in the Palais des Beaux Arts, info here:
http://www.fortified-places.com/reliefs/beauxarts.html